The rational use of thromboprophylaxis therapy in hospitalized patients and the perspectives of health care providers in Northern Cyprus

PLoS One. 2020 Jul 15;15(7):e0235495. doi: 10.1371/journal.pone.0235495. eCollection 2020.

Abstract

Background: Despite the presence of effective strategies and standard guidelines for the prevention of deep vein thrombosis (DVT), a considerable proportion of patients at risk of developing thromboembolism did not receive prophylaxis during hospitalization, while others received it irrationally, thus led to unwanted side effects.

Aim: This study aimed to evaluate the current thromboprophylaxis practice and management of hospitalized patients at risk of developing DVT, along with the assessment of health care providers (HCPs) knowledge, and attitudes regarding DVT prevention.

Methods: An observational study was conducted in the general wards of two leading tertiary university hospitals in Northern Cyprus in which patients from multiple clinics were enrolled to investigate the rational use of DVT prophylaxis using the Caprini risk assessment tool. Patients were also followed for possible complications two weeks post-hospitalization. A cross-sectional study followed to assess the knowledge and attitude of HCPs regarding DVT risks and prophylaxis.

Results: Of the 180 patients enrolled, 47.7% were identified as irrationally managed, 52.3% were identified as rationally managed, 77.8% of patients were identified as having a high level of risk. Notably, Four of thirteen patients who received more thromboprophylaxis developed minor complications. Additionally, 73.3% of nurses had not received DVT education. Furthermore, more than 50% of physicians and nurses achieved a low knowledge score for DVT risks and prophylaxis.

Conclusions: A high degree of irrationality in the administration of thromboprophylaxis therapy to hospitalized patients was observed. The overall scores for HCPs indicated insufficient knowledge of DVT risk assessments and prophylaxis.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Cyprus
  • Female
  • Health Knowledge, Attitudes, Practice
  • Health Personnel / statistics & numerical data*
  • Hospitalization*
  • Humans
  • Male
  • Middle Aged
  • Risk Adjustment
  • Venous Thrombosis / prevention & control*
  • Venous Thrombosis / therapy

Grants and funding

The author(s) received no specific funding for this work.