Whole-genome methylome analysis reveals age-related diabetes risk factors

Luo Hai; Zongzhi Liu; Wei Chen; Jie Qiao; Yingli Sun

doi:10.1002/ctm2.93

Whole-genome methylome analysis reveals age-related diabetes risk factors

Clin Transl Med. 2020 Jul;10(3):e93. doi: 10.1002/ctm2.93. Epub 2020 Jul 15.

Authors

Luo Hai¹, Zongzhi Liu^{1

2}, Wei Chen^{3

4

5

6

7

8}, Jie Qiao^{3

8}, Yingli Sun^{1

2

3}

Affiliations

¹ Central Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
² International College, University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
⁴ National Clinical Research Center for Obstetrics and Gynecology, Beijing, China.
⁵ Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China.
⁶ Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
⁷ Beijing Advanced Innovation Center for Genomics, Beijing, China.
⁸ Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

PMID: 32667725
PMCID: PMC7418808
DOI: 10.1002/ctm2.93

Abstract

This study provides a new perspective on the relationship between age-related DNA methylation and insulin function. The hexokinase-1 (HK1)'s methylation level in the whole blood can be considered as a potential biomarker for the risk of diabetes in healthy individuals.

Keywords: DNA methylation; age; insulin resistance; insulin secretion.

Publication types

Letter

Abstract

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