Fabrication of an injectable BMSC-laden double network hydrogel based on silk fibroin/PEG for cartilage repair

J Mater Chem B. 2020 Jul 15;8(27):5845-5848. doi: 10.1039/d0tb01017k.

Abstract

An injectable BMSC-encapsulated double network (DN) hydrogel was fabricated via silk fibroin (SF) and poly(ethylene glycol) (PEG), which could efficiently support the survival and proliferation of BMSCs in vitro as well as cartilage repair in vivo, and provides a new strategy for cartilage tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Cartilage / metabolism*
  • Chondrogenesis
  • Fibroins / chemistry*
  • Humans
  • Hydrogels / chemistry*
  • Polyethylene Glycols / chemistry*
  • Rats
  • Rats, Sprague-Dawley
  • Tissue Scaffolds / chemistry*

Substances

  • Biocompatible Materials
  • Hydrogels
  • Polyethylene Glycols
  • Fibroins