NOTCH Your Usual Suspect: MYC Charged with Controlling Neuroendocrine Cell-Fate in Small Cell Lung Cancer

Jin Ng; Kate D Sutherland

doi:10.1016/j.ccell.2020.06.009

NOTCH Your Usual Suspect: MYC Charged with Controlling Neuroendocrine Cell-Fate in Small Cell Lung Cancer

Cancer Cell. 2020 Jul 13;38(1):17-20. doi: 10.1016/j.ccell.2020.06.009.

Authors

Jin Ng¹, Kate D Sutherland²

Affiliations

¹ ACRF Cancer Biology and Stem Cell Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3052, Australia.
² ACRF Cancer Biology and Stem Cell Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: sutherland.k@wehi.edu.au.

PMID: 32663464
DOI: 10.1016/j.ccell.2020.06.009

Abstract

Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland et al. demonstrate that MYC mediates neuroendocrine cell plasticity in SCLC by activating NOTCH signaling. This MYC-NOTCH axis controls the dynamic behavior of tumor cells, resulting in the co-existence of SCLC subtypes within individual tumors.

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MeSH terms

Cell Differentiation
Humans
Lung Neoplasms* / genetics
Neuroendocrine Cells*
Signal Transduction
Small Cell Lung Carcinoma* / genetics