Neurophysiological aspects of auditory hallucinations. 99mTc-(HMPAO)-SPECT investigations in patients with auditory hallucinations and normal controls--a preliminary report

M Musalek; I Podreka; E Suess; D Nutzinger; V Passweg; R Strobl; H Walter; C Baumgartner; O M Lesch

doi:10.1159/000284570

Neurophysiological aspects of auditory hallucinations. 99mTc-(HMPAO)-SPECT investigations in patients with auditory hallucinations and normal controls--a preliminary report

Psychopathology. 1988;21(6):275-80. doi: 10.1159/000284570.

Authors

M Musalek¹, I Podreka, E Suess, D Nutzinger, V Passweg, R Strobl, H Walter, C Baumgartner, O M Lesch

Affiliation

¹ Department of Psychiatry, University of Vienna, Austria.

PMID: 3266341
DOI: 10.1159/000284570

Abstract

In a symptom-oriented study 17 patients suffering from chronic auditory hallucinations were investigated by means of 99mTc-HMPAO-SPECT and compared with healthy controls. The results confirm the relative frontal hypoactivity in junction with a relative hyperactivity in the basal ganglia and mesial limbic structures in both hemispheres found in a previous pilot study in auditorily hallucinating patients. Our results should fortify the symptom-oriented approach in psychiatric research.

MeSH terms

Adult
Auditory Perception / physiology*
Basal Ganglia / blood supply
Brain / blood supply*
Brain Mapping / methods
Dominance, Cerebral / physiology
Female
Frontal Lobe / blood supply
Hallucinations / physiopathology*
Hippocampus / blood supply
Humans
Male
Middle Aged
Organometallic Compounds
Oximes
Psychotic Disorders / physiopathology*
Regional Blood Flow
Technetium Tc 99m Exametazime
Tomography, Emission-Computed / methods*

Substances

Organometallic Compounds
Oximes
Technetium Tc 99m Exametazime