Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): Comprehensive management of a newly diagnosed young adult

Gynecol Oncol. 2020 Sep;158(3):538-546. doi: 10.1016/j.ygyno.2020.06.160. Epub 2020 Jul 10.

Abstract

SCCOHT is an aggressive malignancy linked to alterations of SMARCA4. We describe the diagnosis and therapy of a 32 year old who received multi-agent chemotherapy and underwent a second look operation with HIPEC followed by high-dose chemotherapy with stem cell transplant. Supportive care, oncofertility, and genetic counseling are described.

Keywords: AYA; Ovarian; Rhabdoid; SCCOHT; SMARCA4; Transplant.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carcinoma, Small Cell / diagnosis*
  • Carcinoma, Small Cell / genetics
  • Carcinoma, Small Cell / therapy*
  • DNA Helicases / genetics
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Hypercalcemia / diagnosis
  • Hypercalcemia / genetics
  • Hypercalcemia / therapy
  • Hyperthermic Intraperitoneal Chemotherapy
  • Nuclear Proteins / genetics
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / therapy*
  • Transcription Factors / genetics

Substances

  • Nuclear Proteins
  • Transcription Factors
  • SMARCA4 protein, human
  • DNA Helicases