Abstract
SCCOHT is an aggressive malignancy linked to alterations of SMARCA4. We describe the diagnosis and therapy of a 32 year old who received multi-agent chemotherapy and underwent a second look operation with HIPEC followed by high-dose chemotherapy with stem cell transplant. Supportive care, oncofertility, and genetic counseling are described.
Keywords:
AYA; Ovarian; Rhabdoid; SCCOHT; SMARCA4; Transplant.
Copyright © 2020. Published by Elsevier Inc.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Carcinoma, Small Cell / diagnosis*
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Carcinoma, Small Cell / genetics
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Carcinoma, Small Cell / therapy*
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DNA Helicases / genetics
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Female
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Hematopoietic Stem Cell Transplantation
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Humans
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Hypercalcemia / diagnosis
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Hypercalcemia / genetics
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Hypercalcemia / therapy
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Hyperthermic Intraperitoneal Chemotherapy
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Nuclear Proteins / genetics
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Ovarian Neoplasms / diagnosis*
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / therapy*
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Transcription Factors / genetics
Substances
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Nuclear Proteins
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Transcription Factors
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SMARCA4 protein, human
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DNA Helicases