RNA-binding proteins in tumor progression

J Hematol Oncol. 2020 Jul 11;13(1):90. doi: 10.1186/s13045-020-00927-w.

Abstract

RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA, including regulating RNA splicing, polyadenylation, mRNA stability, mRNA localization, and translation. Alteration of each process will affect the RNA life cycle, produce abnormal protein phenotypes, and thus lead to the occurrence and development of tumors. Here, we summarize RBPs involved in tumor progression and the underlying molecular mechanisms whereby they are regulated and exert their effects. This analysis is an important step towards the comprehensive characterization of post-transcriptional gene regulation involved in tumor progression.

Keywords: Polyadenylation; RNA splicing; RNA-binding proteins; mRNA localization carcinoma; mRNA stability.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing
  • Chromatin Assembly and Disassembly
  • DNA Damage
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasm Proteins / physiology*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Polyadenylation
  • Protein Biosynthesis
  • Protein Processing, Post-Translational
  • RNA Processing, Post-Transcriptional
  • RNA Splicing
  • RNA Stability
  • RNA, Neoplasm / metabolism*
  • RNA, Untranslated / metabolism
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / physiology*
  • Subcellular Fractions / metabolism
  • Transcription, Genetic

Substances

  • Neoplasm Proteins
  • RNA, Neoplasm
  • RNA, Untranslated
  • RNA-Binding Proteins