A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology

Xiaowen Jiang; Hongyuan Lu; Jingda Li; Wenwu Liu; Qiong Wu; Zihua Xu; Qinglong Qiao; Haotian Zhang; Huiyuan Gao; Qingchun Zhao

doi:10.1002/ctm2.50

A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology

Clin Transl Med. 2020 Jul;10(3):e50. doi: 10.1002/ctm2.50. Epub 2020 Jul 11.

Authors

Xiaowen Jiang^{1

2

3}, Hongyuan Lu^{3

4}, Jingda Li^{1

2

3}, Wenwu Liu^{1

2

3}, Qiong Wu^{2

4}, Zihua Xu^{2

3}, Qinglong Qiao⁵, Haotian Zhang⁴, Huiyuan Gao^{1

3}, Qingchun Zhao^{1

2

3

4}

Affiliations

¹ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
² Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.
³ School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
⁴ School of Life Sciences, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
⁵ Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People's Republic of China.

PMID: 32652879
PMCID: PMC7418795
DOI: 10.1002/ctm2.50

No abstract available

Publication types

Letter

Publication types

Grants and funding