Towards brain-tissue-like biomaterials

Eneko Axpe; Gorka Orive; Kristian Franze; Eric A Appel

doi:10.1038/s41467-020-17245-x

Towards brain-tissue-like biomaterials

Nat Commun. 2020 Jul 9;11(1):3423. doi: 10.1038/s41467-020-17245-x.

Authors

Eneko Axpe^{1

2}, Gorka Orive^{3

4

5

6}, Kristian Franze⁷, Eric A Appel^{8

9}

Affiliations

¹ Department of Materials Science & Engineering, Stanford University, Stanford, CA, 94305, USA.
² Space Biosciences Division, Ames Research Center, NASA, Mountain View, CA, 94035, USA.
³ NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
⁴ Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain.
⁵ University Institute for Regenerative Medicine and Oral Implantology-UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain.
⁶ Discovery Tower, Singapore Eye Research Institute, The Academia, Singapore, Singapore.
⁷ Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK.
⁸ Department of Materials Science & Engineering, Stanford University, Stanford, CA, 94305, USA. eappel@stanford.edu.
⁹ Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. eappel@stanford.edu.

Abstract

Many biomaterials have been developed which aim to match the elastic modulus of the brain for improved interfacing. However, other properties such as ultimate toughness, tensile strength, poroviscoelastic responses, energy dissipation, conductivity, and mass diffusivity also need to be considered.

MeSH terms

Biocompatible Materials / pharmacology*
Biomechanical Phenomena
Brain / physiology*
Humans
Research
Tissue Engineering

Substances

Biocompatible Materials