Abstract
In current usage ‘concussion’ describes a clinical presentation, but does not identify the underlying pathological process and therefore cannot be considered a true diagnosis. However, mounting evidence indicates diffuse axonal injury as a likely pathological substrate for concussion, thereby providing a framework to develop true diagnostic criteria.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Athletic Injuries / blood
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Athletic Injuries / diagnostic imaging
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Biomarkers / blood
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Brain / diagnostic imaging*
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Brain / metabolism
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Brain Concussion / blood
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Brain Concussion / diagnostic imaging*
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Brain Injuries, Diffuse / diagnostic imaging*
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Brain Injuries, Diffuse / metabolism
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Humans