Oligodendroglioma

Excerpt

Oligodendroglioma (OG) is a type of diffusely infiltrating glioma and constitutes approximately 5% of primary intracranial tumors. They often involve the cortical gray matter and are most commonly seen in the frontal lobes. Historically OG was diagnosed based on the histological appearance of the tumor. However, in 2016 the WHO changed the criteria for the classification of CNS tumors to include both phenotypic and genotypic analysis. OGs are generally low-grade WHO grade II neoplasms that are slow-growing tumors and have a favorable treatment response when compared to other gliomas. Grade III anaplastic OG is a more malignant form of the tumor that portends a less favorable prognosis and may occur de novo or as degeneration from the lower grade OG.