CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

Philipp Sievers; Thomas Hielscher; Daniel Schrimpf; Damian Stichel; David E Reuss; Anna S Berghoff; Marian C Neidert; Hans-Georg Wirsching; Christian Mawrin; Ralf Ketter; Werner Paulus; Guido Reifenberger; Katrin Lamszus; Manfred Westphal; Nima Etminan; Miriam Ratliff; Christel Herold-Mende; Stefan M Pfister; David T W Jones; Michael Weller; Patrick N Harter; Wolfgang Wick; Matthias Preusser; Andreas von Deimling; Felix Sahm

doi:10.1007/s00401-020-02188-w

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

Acta Neuropathol. 2020 Sep;140(3):409-413. doi: 10.1007/s00401-020-02188-w. Epub 2020 Jul 8.

Authors

Philipp Sievers^#^{1

2}, Thomas Hielscher^#³, Daniel Schrimpf^{1

2}, Damian Stichel^{1

2}, David E Reuss^{1

2}, Anna S Berghoff⁴, Marian C Neidert⁵, Hans-Georg Wirsching⁶, Christian Mawrin⁷, Ralf Ketter⁸, Werner Paulus⁹, Guido Reifenberger^{10

11}, Katrin Lamszus¹², Manfred Westphal¹², Nima Etminan¹³, Miriam Ratliff¹³, Christel Herold-Mende¹⁴, Stefan M Pfister^{15

16

17}, David T W Jones^{15

18}, Michael Weller⁶, Patrick N Harter^{19

20

21

22}, Wolfgang Wick^{23

24}, Matthias Preusser²⁵, Andreas von Deimling^{1

2}, Felix Sahm^{26

27

28}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
² Clinical Cooperation Unit Neuropathology (B300), German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Institute of Neurology, Medical University of Vienna, Vienna, Austria.
⁵ Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
⁶ Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
⁷ Department of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
⁸ Department of Neurosurgery, University Hospital Homburg Saar, Homburg, Germany.
⁹ Institute of Neuropathology, University Hospital Münster, Münster, Germany.
¹⁰ Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
¹¹ German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany.
¹² Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹³ Department of Neurosurgery, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.
¹⁴ Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
¹⁵ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
¹⁶ Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁷ Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
¹⁸ Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁹ Institute of Neurology (Edinger Institute), Goethe University, Frankfurt, Germany.
²⁰ German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.
²¹ German Cancer Research Center (DKFZ), Heidelberg, Germany.
²² Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.
²³ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
²⁴ Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
²⁵ Department of Medicine I, Clinical Division of Oncology and Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
²⁶ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
²⁷ Clinical Cooperation Unit Neuropathology (B300), German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
²⁸ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.

^# Contributed equally.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclin-Dependent Kinase Inhibitor p16 / genetics*
Gene Deletion*
Genes, p16 / physiology
Homozygote*
Humans
Meningeal Neoplasms / genetics*
Meningioma / genetics*
Sequence Deletion / genetics

Substances

CDKN2A protein, human
Cyclin-Dependent Kinase Inhibitor p16