Abstract
Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as determined by in vivo positron emission tomography imaging.
MeSH terms
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Animals
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Cobalt / chemistry*
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Contrast Media / chemistry
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Emulsions / chemistry*
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Estradiol / chemistry
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Fatty Acids, Omega-3 / chemistry
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Fatty Acids, Omega-3 / metabolism*
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Lung / diagnostic imaging
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Lung / metabolism
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Nanostructures / chemistry*
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Oils / chemistry
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Positron Emission Tomography Computed Tomography
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Solubility
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Water / chemistry
Substances
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Contrast Media
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Emulsions
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Fatty Acids, Omega-3
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Oils
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Water
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Cobalt
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Estradiol