Neuroharmony: A new tool for harmonizing volumetric MRI data from unseen scanners

Rafael Garcia-Dias; Cristina Scarpazza; Lea Baecker; Sandra Vieira; Walter H L Pinaya; Aiden Corvin; Alberto Redolfi; Barnaby Nelson; Benedicto Crespo-Facorro; Colm McDonald; Diana Tordesillas-Gutiérrez; Dara Cannon; David Mothersill; Dennis Hernaus; Derek Morris; Esther Setien-Suero; Gary Donohoe; Giovanni Frisoni; Giulia Tronchin; João Sato; Machteld Marcelis; Matthew Kempton; Neeltje E M van Haren; Oliver Gruber; Patrick McGorry; Paul Amminger; Philip McGuire; Qiyong Gong; René S Kahn; Rosa Ayesa-Arriola; Therese van Amelsvoort; Victor Ortiz-García de la Foz; Vince Calhoun; Wiepke Cahn; Andrea Mechelli

doi:10.1016/j.neuroimage.2020.117127

Neuroharmony: A new tool for harmonizing volumetric MRI data from unseen scanners

Neuroimage. 2020 Oct 15:220:117127. doi: 10.1016/j.neuroimage.2020.117127. Epub 2020 Jul 4.

Authors

Rafael Garcia-Dias¹, Cristina Scarpazza², Lea Baecker³, Sandra Vieira³, Walter H L Pinaya⁴, Aiden Corvin⁵, Alberto Redolfi⁶, Barnaby Nelson⁷, Benedicto Crespo-Facorro⁸, Colm McDonald⁹, Diana Tordesillas-Gutiérrez¹⁰, Dara Cannon⁹, David Mothersill¹¹, Dennis Hernaus¹², Derek Morris¹³, Esther Setien-Suero¹⁴, Gary Donohoe¹¹, Giovanni Frisoni¹⁵, Giulia Tronchin⁹, João Sato¹⁶, Machteld Marcelis¹², Matthew Kempton³, Neeltje E M van Haren¹⁷, Oliver Gruber¹⁸, Patrick McGorry⁷, Paul Amminger⁷, Philip McGuire³, Qiyong Gong¹⁹, René S Kahn²⁰, Rosa Ayesa-Arriola¹⁴, Therese van Amelsvoort¹², Victor Ortiz-García de la Foz¹⁴, Vince Calhoun²¹, Wiepke Cahn²², Andrea Mechelli³

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, United Kingdom. Electronic address: rafael.garcia_dias@kcl.ac.uk.
² Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, United Kingdom; Department of General Psychology, University of Padova, Via Venezia 8, Padova, Italy.
³ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, United Kingdom.
⁴ Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, United Kingdom; Center of Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil.
⁵ Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
⁶ Laboratory of Neuroinformatics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
⁷ Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
⁸ Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Departamento de Psiquiatria, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBIS), Spain; Hospital Universitario Virgen del Rocío, Sevilla, Spain; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.
⁹ Clinical Neuroimaging Laboratory, School of Medicine & Center for Neuroimaging and Cognitive Genomics, NUI Galway University, Galway, Ireland.
¹⁰ Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Spain.
¹¹ School of Psychology & Center for Neuroimaging and Cognitive Genomics, NUI Galway University, Galway, Ireland.
¹² Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht, the Netherlands.
¹³ Discipline of Biochemistry & Center for Neuroimaging and Cognitive Genomics, NUI Galway University, Galway, Ireland.
¹⁴ Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.
¹⁵ Memory Clinic and LANVIE-Laboratory of Neuroimaging of Ageing, University Hospitals and University of Geneva, Geneva, Switzerland; Laboratory of Alzheimer's Neuroimaging and Epidemiology - LANE, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
¹⁶ Center of Mathematics, Computing, and Cognition, Universidade Federal do ABC, Santo André, Brazil.
¹⁷ Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, Netherlands.
¹⁸ Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.
¹⁹ Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
²⁰ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
²¹ Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia; State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
²² Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.

Abstract

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We present Neuroharmony, a harmonization tool for images from unseen scanners.
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We developed Neuroharmony using a total of 15,026 sMRI images.
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The tool was able to reduce scanner-related bias from unseen scans.
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Neuroharmony represents a significant step towards imaging-based clinical tools.
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Neuroharmony is available at https://github.com/garciadias/Neuroharmony.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adolescent
Adult
Aged
Brain / diagnostic imaging*
Female
Humans
Image Processing, Computer-Assisted / methods*
Machine Learning
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Neuroimaging / methods*
Software*
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding