Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage

Sisi Dong; Peipei Liu; Yuhan Luo; Ying Cui; Lilong Song; Yingzhu Chen

doi:10.18632/aging.103511

Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage

Aging (Albany NY). 2020 Jul 7;12(13):13791-13802. doi: 10.18632/aging.103511. Epub 2020 Jul 7.

Authors

Sisi Dong¹, Peipei Liu², Yuhan Luo³, Ying Cui³, Lilong Song³, Yingzhu Chen²

Affiliations

¹ The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.
² Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China.
³ Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou 225001, Jiangsu, China.

Abstract

Intracerebral hemorrhage (ICH) is associated with old age and underlying conditions such as hypertension and diabetes. ICH patients are vulnerable to SARS-CoV-2 infection and develop serious complications as a result of infection. The pathophysiology of ICH patients with SARS-CoV-2 infection includes viral invasion, dysfunction of the ACE2-Ang (1-7)-MasR and ACE-Ang II-AT₁R axes, overactive immune response, cytokine storm, and excessive oxidative stress. These patients have high morbidity and mortality due to hyaline membrane formation, respiratory failure, neurologic deficits, and multiple organ failure.

Keywords: ACE2; Ang (1–7); COVID-19; SARS-CoV-2; intracerebral hemorrhage.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Betacoronavirus
COVID-19
Cerebral Hemorrhage / virology*
Comorbidity
Coronavirus Infections / epidemiology*
Coronavirus Infections / physiopathology*
Humans
Pandemics
Pneumonia, Viral / epidemiology*
Pneumonia, Viral / physiopathology*
Proto-Oncogene Mas
SARS-CoV-2