Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease

Valeriana Cesarini; Eugenia Guida; Federica Campolo; Clara Crescioli; Angela Di Baldassarre; Calogera Pisano; Carmela Rita Balistreri; Giovanni Ruvolo; Emmanuele A Jannini; Susanna Dolci

doi:10.1016/j.mad.2020.111311

Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease

Mech Ageing Dev. 2020 Sep:190:111311. doi: 10.1016/j.mad.2020.111311. Epub 2020 Jul 3.

Affiliations

¹ Unicamillus International University of Rome, Rome, Italy.
² Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
³ Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy.
⁴ Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
⁵ Department of Medicine and Aging Sciences, University of Chieti, Chieti, Italy.
⁶ Department of Surgical Sciences, University of Rome Tor Vergata, Rome, Italy.
⁷ Department of Bio-Medicine, Neuroscience, and Advanced Diagnostics (Bi.N.D.), University of Palermo, Palermo, Italy.
⁸ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁹ Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address: dolci@uniroma2.it.

Abstract

Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied.

Keywords: ECs; Nitric oxide; PDE5; VSMCs; cGMP.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / physiology*
Cyclic Nucleotide Phosphodiesterases, Type 5 / metabolism*
Embryonic Development / physiology
Humans
Muscle, Smooth, Vascular / physiology*
Myocytes, Smooth Muscle / physiology*

Substances

Cyclic Nucleotide Phosphodiesterases, Type 5