Abstract
The chemical investigation of the sponge Stylissa aff. carteri collected around Futuna Islands in the Pacific Ocean led to the isolation of three new dimeric pyrrole 2-aminoimidazole alkaloids (PIAs). Futunamine (1) features an unprecedented pyrrolo[1,2-c]imidazole core, while two other new dimeric PIAs were identified as analogues of palau'amine. Together with other known PIAs isolated from this species, they were shown to exhibit anti-inflammatory and neuroprotective activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Anti-Inflammatory Agents / pharmacology
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Cell Line, Tumor
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Humans
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Imidazoles / chemistry*
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Imidazoles / isolation & purification
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Islands
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Microglia / cytology
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Microglia / drug effects
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Molecular Structure
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Neuroprotective Agents / pharmacology
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Pacific Ocean
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Pyrroles / chemistry*
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Pyrroles / isolation & purification
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Spectrum Analysis / methods
Substances
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Alkaloids
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Anti-Inflammatory Agents
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Imidazoles
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Neuroprotective Agents
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Pyrroles