Full use of the liquid nature of the stationary phase: The development of elution-extrusion counter current chromatography

Abstract

Elution-extrusion counter current chromatography extrudes the most solute retained in the column with the highest possible peak resolution. It can greatly improve the hydrophobic window. In recent years, elution-extrusion counter current chromatography has received extensive attention in the separation of complex samples. This article first reviews the development and application of elution-extrusion counter current chromatography, including its origin, mechanism, advantages and disadvantages, and some representative applications. At the same time, this review also shared our visions and ideas on how to improve the elution-extrusion mode. This article aims to provide certain reference for the research of this technology.

Keywords: elution mode; elution-extrusion counter current chromatography; liquid stationary phases.