Scientific opinion on flavouring group evaluation 77, revision 3 (FGE.77Rev3): consideration of pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting) structurally related to pyridine, pyrrole, indole and quinoline derivatives evaluated by EFSA in FGE.24Rev2

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Vittorio Silano; Claudia Bolognesi; Laurence Castle; Kevin Chipman; Jean-Pierre Cravedi; Karl-Heinz Engel; Paul Fowler; Roland Franz; Konrad Grob; Rainer Gürtler; Trine Husøy; Sirpa Kärenlampi; Maria Rosaria Milana; Karla Pfaff; Gilles Riviere; Jannavi Srinivasan; Maria de Fátima Tavares Poças; Christina Tlustos; Detlef Wölfle; Holger Zorn; Romualdo Benigni; Mona-Lise Binderup; Leon Brimer; Francesca Marcon; Daniel Marzin; Pasquale Mosesso; Gerard Mulder; Agneta Oskarsson; Camilla Svendsen; Jan van Benthem; Maria Anastassiadou; Maria Carfì; Wim Mennes

doi:10.2903/j.efsa.2018.5226

Scientific opinion on flavouring group evaluation 77, revision 3 (FGE.77Rev3): consideration of pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting) structurally related to pyridine, pyrrole, indole and quinoline derivatives evaluated by EFSA in FGE.24Rev2

EFSA J. 2018 Apr 25;16(4):e05226. doi: 10.2903/j.efsa.2018.5226. eCollection 2018 Apr.

Abstract

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the EFSA was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 22 pyridine, pyrrole and quinoline derivatives evaluated by JECFA (63rd meeting). The revision of this consideration is made since additional genotoxicity data have become available for 6-methylquinoline [FL-no: 14.042]. The genotoxicity data available rule out the concern with respect to genotoxicity and accordingly the substance is evaluated through the Procedure. For all 22 substances [FL-no: 13.134, 14.001, 14.004, 14.007, 14.030, 14.038, 14.039, 14.041, 14.042, 14.045, 14.046, 14.047, 14.058, 14.059, 14.060, 14.061, 14.065, 14.066, 14.068, 14.071, 14.072 and 14.164] considered in this Flavouring Group Evaluation (FGE), the Panel agrees with the JECFA conclusion, 'No safety concern at estimated levels of intake as flavouring substances' based on the Maximised Survey-derived Daily Intake (MSDI) approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been evaluated, and the information is considered adequate for all the substances. For the following substances [FL-no: 13.134, 14.001, 14.030, 14.041, 14.042, 14.058, 14.072], the Industry has submitted use levels for normal and maximum use. For the remaining 15 substances, use levels are needed to calculate the modified Theoretical Added Maximum Daily Intakes (mTAMDIs) in order to identify those flavouring substances that need more refined exposure assessment and to finalise the evaluation.

Keywords: 63rd meeting; FGE.24Rev2; FGE.77; JECFA; pyridine; pyrrole; quinoline.