Sequence-directed dynamic covalent assembly of base-4-encoded oligomers

S C Leguizamon; M F Dunn; T F Scott

doi:10.1039/d0cc01083a

Sequence-directed dynamic covalent assembly of base-4-encoded oligomers

Chem Commun (Camb). 2020 Jul 14;56(56):7817-7820. doi: 10.1039/d0cc01083a.

Authors

S C Leguizamon¹, M F Dunn¹, T F Scott²

Affiliations

¹ Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
² Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA and Department of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia. timothy.scott@monash.edu and Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.

PMID: 32618971
DOI: 10.1039/d0cc01083a

Abstract

As an information-bearing biomacromolecule, DNA is encoded in base-4, where each residue site can be occupied by any one of four nucleobases. Mimicking the information dense, sequence-selective hybridization of DNA, we demonstrate two orthogonal dynamic covalent interactions to effect the selective assembly of molecular ladders and grids from base-4-encoded oligo(peptoid)s.