An MRI-visible immunoadjuvant based on hollow Gd2O3 nanospheres for cancer immunotherapy

Xia Li; Xiupeng Wang; Atsuo Ito

doi:10.1039/d0cc03568h

An MRI-visible immunoadjuvant based on hollow Gd₂O₃ nanospheres for cancer immunotherapy

Chem Commun (Camb). 2020 Jul 23;56(59):8186-8189. doi: 10.1039/d0cc03568h.

Authors

Xia Li¹, Xiupeng Wang, Atsuo Ito

Affiliation

¹ Health and Medical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. xp-wang@aist.go.jp.

PMID: 32618297
DOI: 10.1039/d0cc03568h

Abstract

Hollow Gd2O3 nanospheres significantly promote the cellular uptake of a tumor antigen by antigen presenting cells, exhibit pH-dependent alteration of the MR signal intensity and markedly enhance the antitumor immunity. Hollow Gd2O3 nanospheres are promising as magnetic resonance imaging (MRI)-visible cancer immunoadjuvants for cancer immunotherapy.

MeSH terms

Adjuvants, Immunologic / chemistry*
Adjuvants, Immunologic / pharmacology
Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Membrane Permeability / drug effects
Contrast Media / chemistry
Drug Discovery
Gadolinium / chemistry*
Gadolinium / pharmacology
Humans
Immunotherapy
Interleukin-1beta / metabolism
Lymph Nodes / drug effects
Magnetic Resonance Imaging
Mice
Nanospheres / chemistry*
Neoplasms / immunology
Neoplasms / therapy*
Ovalbumin / chemistry
T-Lymphocytes / drug effects

Substances

Adjuvants, Immunologic
Antineoplastic Agents
Contrast Media
Interleukin-1beta
gadolinium oxide
Ovalbumin
Gadolinium