[Research Advances in Follicular Regulatory T Cells in Ocular Myasthenia Gravis]

Na Wu; Yuxiang Hu; Xiaoxuan Xu; Li Yan; Yi Cheng; Jie Rao; Yajun Wu; Xiaorong Wu

doi:10.3881/j.issn.1000-503X.11252

[Research Advances in Follicular Regulatory T Cells in Ocular Myasthenia Gravis]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Jun 30;42(3):383-387. doi: 10.3881/j.issn.1000-503X.11252.

[Article in Chinese]

Authors

Na Wu¹, Yuxiang Hu¹, Xiaoxuan Xu¹, Li Yan¹, Yi Cheng¹, Jie Rao¹, Yajun Wu¹, Xiaorong Wu¹

Affiliation

¹ Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China.

PMID: 32616136
DOI: 10.3881/j.issn.1000-503X.11252

Abstract

Myasthenia gravis(MG)is a B cell-mediated,T cell-dependent,complements-involved autoimmune disease.Ocular myasthenia gravis(OMG)is a typical MG,with its symptoms limited to the extraocular muscles.The occurrence and development of a variety of autoimmune diseases including OMG are closely associated with the imbalanced expression of follicular regulatory T cells(Tfr cells).Therefore,Tfr cells may be a new research topic for OMG.

Keywords: follicular help T cells; follicular regulatory T cells; germinal center; ocular myasthenia gravis; pathogenesis.

MeSH terms

Complement System Proteins
Humans
Myasthenia Gravis*
Oculomotor Muscles
T-Lymphocytes, Regulatory*

Substances

Complement System Proteins