Pregnancy and Delivery in Women with Lower Urinary Tract Reconstruction: A National Multicenter Retrospective Study from the French-Speaking Neuro-Urology Study Group (GENULF) and the Neuro-Urology Committee of the French Association of Urology

J Urol. 2020 Dec;204(6):1263-1269. doi: 10.1097/JU.0000000000001233. Epub 2020 Jul 2.

Abstract

Purpose: Management of pregnancy and delivery in women with lower urinary tract reconstruction is challenging and the currently available literature is insufficient to guide clinical practice. We report pregnancy and delivery outcomes in this specific population.

Materials and methods: We conducted a national multicenter retrospective study (16 centers) including 68 women with 96 deliveries between 1998 and 2019. These women had at least 1 successful pregnancy and delivery after augmentation enterocystoplasty, catheterizable channel creation and/or artificial urinary sphincter implantation. Maternal and fetal complications during pregnancy and delivery were reported, as well as postpartum functional outcomes, according to the delivery mode. The chi-square test and Student's t-test were used to compare categorical and continuous variables, respectively.

Results: Overall 32% of reported pregnancies were complicated by febrile urinary tract infections, 13.5% by renal colic and 14.6% required upper urinary tract diversion. In addition, 10% of patients reported transient self-catheterization difficulties and 13.5% reported de novo or increased urinary incontinence. The preterm delivery rate was 35.3%. Elective C-section was performed in 61% of pregnancies. Twenty complications occurred during delivery (20%), including 19 during elective C-section. Urinary continence at 1 year was unchanged for 93.5% of deliveries. Delivery mode (p=0.293) and multiparity (p=0.572) had no impact on urinary continence.

Conclusions: In this population C-section appeared to be associated with a high risk of complications. In the absence of any obstetric or neurological contraindications, vaginal delivery should be proposed as the first line option to the majority of these women.

Keywords: artificial; delivery; obstetric; urinary diversion; urinary sphincter.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Cesarean Section / adverse effects*
  • Cesarean Section / statistics & numerical data
  • Female
  • France / epidemiology
  • Humans
  • Multiple Sclerosis / surgery
  • Plastic Surgery Procedures / adverse effects*
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Pregnancy Complications / etiology
  • Pregnancy Complications / surgery
  • Premature Birth / epidemiology*
  • Premature Birth / etiology
  • Renal Colic / epidemiology
  • Renal Colic / etiology
  • Retrospective Studies
  • Spinal Cord Injuries / surgery
  • Spinal Dysraphism / surgery
  • Urinary Bladder / abnormalities
  • Urinary Bladder / surgery
  • Urinary Diversion / statistics & numerical data
  • Urinary Incontinence / epidemiology
  • Urinary Incontinence / etiology
  • Urinary Sphincter, Artificial / adverse effects
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / etiology
  • Young Adult