Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

Man-Man Xu; Tong-Tong Jia; Bingjie Li; Wang Ma; Xiaoyuan Chen; Xueli Zhao; Shuang-Quan Zang

doi:10.1039/d0cc03498c

Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

Chem Commun (Camb). 2020 Aug 4;56(62):8766-8769. doi: 10.1039/d0cc03498c.

Authors

Man-Man Xu¹, Tong-Tong Jia¹, Bingjie Li², Wang Ma², Xiaoyuan Chen³, Xueli Zhao¹, Shuang-Quan Zang¹

Affiliations

¹ Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. xuelizhao@zzu.edu.cn zangsqzg@zzu.edu.cn.
² The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
³ Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA.

PMID: 32613976
DOI: 10.1039/d0cc03498c

Abstract

A structure-determined gold-levonorgestrel nanocluster, Au10(C21H27O2)10 (Au10NC), has been obtained via solvent induced crystal transformation from Au8(C21H27O2)8 (Au8NC), accompanied by a fluorescence color change from green to yellow. A cationic polymer, poly(allylamine hydrochloride) (PAH), was chosen to assemble with Au10NC to prepare monodisperse and stable particles (Au10NC-PAH) with an increased quantum yield of 49.8%. The as-fabricated Au10NC-PAH realized effective antibody-mediated actin imaging and sustained drug release.

MeSH terms

Cell Line
Color
Drug Carriers / chemistry*
Gold / chemistry*
Nanostructures / chemistry*
Solvents / chemistry
Staining and Labeling

Substances

Drug Carriers
Solvents
Gold