Sweet syndrome with pulmonary involvement in a patient with myelodysplastic syndrome

Dermatol Online J. 2020 Mar 15;26(3):13030/qt1n73f6k5.

Abstract

We report a patient with Sweet syndrome involving the pulmonary system in the context of myelodysplastic syndrome. Although Sweet syndrome may involve a variety of organ systems, the pulmonary system is rarely affected and can result in poor clinical outcomes, including acute respiratory distress syndrome. Both cutaneous and pulmonary symptoms respond well to systemic corticosteroid therapy and early diagnosis and treatment can improve the prognosis. Our case highlights the importance of collaboration between hematologists, dermatologists, and pulmonologists to facilitate effective diagnosis, triage, and treatment of these patients.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Female
  • Glucocorticoids / therapeutic use
  • Histone-Lysine N-Methyltransferase / genetics
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases / diagnostic imaging
  • Lung Diseases / pathology
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Myelodysplastic Syndromes / complications*
  • Myeloid-Lymphoid Leukemia Protein / genetics
  • Pancytopenia / complications
  • Sweet Syndrome / diagnosis*
  • Sweet Syndrome / drug therapy
  • Sweet Syndrome / pathology
  • Tomography, X-Ray Computed

Substances

  • Glucocorticoids
  • KMT2A protein, human
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase
  • Methylprednisolone