Risk Factors for Postoperative Infectious Complications in Elderly Patients with Gastric Cancer

Xiao Liu; Zhigang Xue; Jianchun Yu; Zijian Li; Zhiqiang Ma; Weiming Kang; Xin Ye; Lin Jiang

doi:10.2147/CMAR.S253649

Risk Factors for Postoperative Infectious Complications in Elderly Patients with Gastric Cancer

Cancer Manag Res. 2020 Jun 9:12:4391-4398. doi: 10.2147/CMAR.S253649. eCollection 2020.

Authors

Xiao Liu¹, Zhigang Xue^{2

3}, Jianchun Yu², Zijian Li^{2

3}, Zhiqiang Ma², Weiming Kang², Xin Ye², Lin Jiang^{2

3}

Affiliations

¹ Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
² Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
³ Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Abstract

Background: Elderly patients with gastric cancer (GC) are at increased risk of infectious complications following gastrectomy. A limited set of risk factors has been identified to predict complications in these patients. To improve the safety of gastrectomy in this population, we investigated the incidence of infectious complications and associated clinicopathologic, nutritional and surgical risk factors in a cohort of elderly patients with GC.

Methods: Elderly GC patients (≥70 years) who underwent gastrectomy between January 2013 and December 2017 in Peking Union Medical College Hospital were included in the study. Clinicopathologic data were collected retrospectively. Severity of complications was classified using the Clavien-Dindo system. Infectious complications were assessed based on clinical diagnosis of health care-associated infection as defined by the US Centers for Disease Control and Prevention. Multivariate logistic regression analyses were performed to determine the risk factors for infectious complications.

Results: Three hundred thirty-one consecutive patients were included, with a median age of 74 years (range 70-88). The rate of surgical morbidity was 37.5% and the mortality rate was 1.2%. The incidence of infectious complications was 19.6%, with the most common infectious complication being pulmonary infection (11.5%). Preoperative weight loss ≥5% (odds ratio [OR] = 2.21; 95% CI, 1.15-4.28; p = 0.018), Charlson comorbidity index score ≥3 (OR = 2.83; 95% CI, 1.30-6.16; p = 0.009) and preoperative hsCRP level ≥10 mg/L (OR = 2.48; 95% CI, 1.14-5.38; p = 0.022) were independently associated with infectious complications.

Conclusion: Preoperative weight loss, elevated hsCRP level and comorbidity burden can be used to predict postoperative infectious complications in elderly GC patients. It is recommended to pay more attention to the treatment of elderly GC patients with these risk factors.

Keywords: complications; elderly; gastric cancer; risk factors; weight loss.

Grants and funding

This study was funded by the Beijing Municipal Science and Technology Commission Program, Early Diagnosis and Standardized Treatment of Gastric Cancer (D141100000414002) and Research on the Standardized Treatment in Elderly Gastric Cancer Patients (D171100006517002); National Health and Family Planning Commission of China Program, Establishment of Standardized Clinical Nutrition System in Surgical Patients (201502022).