Abstract
The rapid synthesis of an amide hydrogen bond templated [1]rotaxane is reported - demonstrating a potential pathway to synthetic analogues of lasso peptides. The structures of the [1]rotaxane and its unthreaded isomer have been characterized by NMR spectroscopy and modelled using DFT calculations.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Density Functional Theory
-
Hydrogen Bonding
-
Molecular Mimicry
-
Nerve Tissue Proteins / chemistry*
-
Nuclear Magnetic Resonance, Biomolecular
-
Peptides / chemistry*
-
Rats
-
Rotaxanes / chemistry*
Substances
-
Nerve Tissue Proteins
-
Peptides
-
Rotaxanes