The mussel-inspired assisted apatite mineralized on PolyJet material for artificial bone scaffold

Yi-Wen Chen; Hsin-Yuan Fang; Ming-You Shie; Yu-Fang Shen

doi:10.18063/ijb.v5i2.197

The mussel-inspired assisted apatite mineralized on PolyJet material for artificial bone scaffold

Int J Bioprint. 2019 Jul 11;5(2):197. doi: 10.18063/ijb.v5i2.197. eCollection 2019.

Authors

Yi-Wen Chen^{1

2}, Hsin-Yuan Fang^{1

3

4}, Ming-You Shie^{1

5}, Yu-Fang Shen^{6

7}

Affiliations

¹ Three-dimensional Printing Medical Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.
² Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
³ Department of Thoracic Surgery, China Medical University Hospital, Taichung, Taiwan.
⁴ School of Medicine, China Medical University, Taichung, Taiwan.
⁵ School of Dentistry, China Medical University, Taichung, Taiwan.
⁶ Three-dimensional Printing Medical Research Institute, Asia University, Taichung, Taiwan.
⁷ Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.

Abstract

With the development of three-dimensional (3D) printing, many commercial 3D printing materials have been applied in the fields of biomedicine and medical. MED610 is a clear, biocompatible PolyJet material that is medically certified for bodily contact. In this study, the polydopamine (PDA)/hydroxyapatite (HA) coating was added to the printed MED610 objects to evaluate its physical properties, cell proliferation, cell morphology, and alkaline phosphatase expression level. The results show that the PDA/HA coating helps printed objects to enhance the hardness, biocompatibility, and osteogenic differentiation potential. We expect that PDA/HA coatings contribute to the applicability of MED610 in biomedical and medical applications.

Keywords: Hydroxyapatite; MED610; Osteogenic differentiation; PolyJet technology; Polydopamine; Three-dimensional printing.