Colorectal surgery is a major therapeutic approach for various colorectal diseases. Surgery and perioperative management, such as fasting, mechanical bowel preparation, and antibiotics use, have an impact on the composition and function of gut microbiome. Abnormal microbiome reconstruction may lead to multiple complications, including infection, gastrointestinal dysfunction, anastomotic leak and disease recurrence. The aim of this review is to elucidate the roles and mechanisms of perioperative interventions of colorectal surgery on gut microbiome, which may provide a novel insight into the microbe-based therapies in the perioperative period of colorectal surgery.
手术是多种结直肠疾病的主要治疗手段。手术及围手术期处理（如术前禁食、机械性肠道准备、抗生素的使用）可改变肠道菌群的构成和功能。肠道菌群失调可增加术后感染、胃肠功能失调、吻合口漏及疾病复发等风险。本文探讨了结直肠外科围手术期干预对肠道菌群的影响及其作用机制，为围手术期的微生态干预提供新的视角及理论依据。.
Keywords: Colorectal surgery; Dysbiosis; Microbiome; Perioperative period; Postoperative complications.