Gata2 -77 enhancer regulates adult hematopoietic stem cell survival

Xiaona You; Yuan-I Chang; Guangyao Kong; Erik A Ranheim; Yun Zhou; Kirby D Johnson; Charu Mehta; Emery H Bresnick; Jing Zhang

doi:10.1038/s41375-020-0942-6

Gata2 -77 enhancer regulates adult hematopoietic stem cell survival

Leukemia. 2021 Mar;35(3):901-905. doi: 10.1038/s41375-020-0942-6. Epub 2020 Jun 27.

Authors

Xiaona You^{1

2}, Yuan-I Chang^{1

3}, Guangyao Kong^{1

4}, Erik A Ranheim⁵, Yun Zhou^{1

2}, Kirby D Johnson^{2

6}, Charu Mehta^{2

6}, Emery H Bresnick^{2

6}, Jing Zhang^{7

8}

Affiliations

¹ McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.
² University of Wisconsin-Madison Blood Research Program, Madison, WI, USA.
³ Institute of Physiology, National Yang-Ming University, Taipei City, Taiwan.
⁴ National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
⁵ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
⁶ Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁷ McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA. zhang@oncology.wisc.edu.
⁸ University of Wisconsin-Madison Blood Research Program, Madison, WI, USA. zhang@oncology.wisc.edu.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Animals
Enhancer Elements, Genetic*
GATA2 Transcription Factor / genetics
GATA2 Transcription Factor / physiology*
Gene Expression Regulation, Neoplastic*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism
Leukemia, Experimental / genetics
Leukemia, Experimental / metabolism
Leukemia, Experimental / pathology*
Mice
Mice, Knockout

Substances

GATA2 Transcription Factor
Gata2 protein, mouse

Publication types

MeSH terms

Substances

Grants and funding