Unfolded protein response in cardiovascular disease

Khadeja-Tul Kubra; Mohammad S Akhter; Mohammad A Uddin; Nektarios Barabutis

doi:10.1016/j.cellsig.2020.109699

Unfolded protein response in cardiovascular disease

Cell Signal. 2020 Sep:73:109699. doi: 10.1016/j.cellsig.2020.109699. Epub 2020 Jun 25.

Authors

Khadeja-Tul Kubra¹, Mohammad S Akhter¹, Mohammad A Uddin¹, Nektarios Barabutis²

Affiliations

¹ School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
² School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA. Electronic address: barabutis@ulm.edu.

PMID: 32592779
DOI: 10.1016/j.cellsig.2020.109699

Abstract

The unfolded protein response (UPR) is a highly conserved molecular machinery, which protects the cells against a diverse variety of stimuli. Activation of this element has been associated with both human health and disease. The purpose of the current manuscript is to provide the most updated information on the involvement of UPR towards the improvement; or deterioration of cardiovascular functions. Since UPR is consisted of three distinct elements, namely the activating transcription factor 6, the protein kinase RNA-like endoplasmic reticulum kinase; and the inositol-requiring enzyme-1α, a highly orchestrated manipulation of those molecular branches may provide new therapeutic possibilities against the severe outcomes of cardiovascular disease.

Keywords: Arrhythmia; Cardiac hypertrophy; ER stress; Myocardial infarction.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiovascular Diseases / metabolism*
Endoplasmic Reticulum Stress*
Humans
Unfolded Protein Response*