Complete genome sequence of a potential foot-and-mouth disease virus serotype O vaccine strain from Bangladesh

Md Al Amin; Md Rahmat Ali; A S M Rubayet Ul Alam; Mohammad Anwar Siddique; Md Mizanur Rahaman; Munawar Sultana; Md Anwar Hossain

doi:10.1007/s00705-020-04711-6

Complete genome sequence of a potential foot-and-mouth disease virus serotype O vaccine strain from Bangladesh

Arch Virol. 2020 Sep;165(9):2119-2122. doi: 10.1007/s00705-020-04711-6. Epub 2020 Jun 26.

Authors

Md Al Amin^{1

2}, Md Rahmat Ali^{1

3}, A S M Rubayet Ul Alam^{1

4}, Mohammad Anwar Siddique^{1

5}, Md Mizanur Rahaman¹, Munawar Sultana¹, Md Anwar Hossain^{6

7}

Affiliations

¹ Department of Microbiology, University of Dhaka, Dhaka, 1000, Bangladesh.
² Quality Control Laboratory, Department of Livestock Services, Savar, Dhaka, Bangladesh.
³ Ministry of Foreign Affairs, Dhaka, Bangladesh.
⁴ Department of Microbiology, Jashore University of Science and Technology, Jashore, 7408, Bangladesh.
⁵ Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
⁶ Department of Microbiology, University of Dhaka, Dhaka, 1000, Bangladesh. hossaina@du.ac.bd.
⁷ Jashore University of Science and Technology, Jashore, 7408, Bangladesh. hossaina@du.ac.bd.

PMID: 32591914
DOI: 10.1007/s00705-020-04711-6

Abstract

One of the six sublineages of the dominant O/ME-SA/Ind2001 lineage of foot-and-mouth disease virus (FMDV), Ind2001BD1 has already spread throughout 14 countries, including Bangladesh. Here, we report the complete genome sequence of the potential serotype O vaccine strain BAN/TA/Dh-301/2016, which has been shown to provide protection against all the circulating serotype O viruses in Bangladesh. The viral genome is 8,211 nucleotide (nt) long with an open reading frame (ORF) of 6999 nt. The ORF is flanked by a 1098-nt-long 5'-UTR and a 114-nt-long 3'-UTR. Compared to the Indian FMDV serotype O vaccine strain O/India/R2/75 (AF204276), ten mutations were identified in the major antigenic sites of BAN/TA/Dh-301/2016 (MK088170.1).

MeSH terms

Animals
Bangladesh
Base Sequence
Cattle
Cattle Diseases / virology
Foot-and-Mouth Disease / virology*
Foot-and-Mouth Disease Virus / classification
Foot-and-Mouth Disease Virus / genetics*
Foot-and-Mouth Disease Virus / immunology
Foot-and-Mouth Disease Virus / isolation & purification
Genome, Viral*
Mutation
Open Reading Frames
Viral Proteins / genetics
Viral Proteins / immunology
Viral Vaccines / genetics
Whole Genome Sequencing

Substances

Viral Proteins
Viral Vaccines

Grants and funding

CP-3842/Higher Education Quality Enhancement Project (HEQEP) grant number, University Grants Commission (UGC)