Physical triggering strategies for drug delivery

Tao Sun; Anshuman Dasgupta; Zongmin Zhao; Md Nurunnabi; Samir Mitragotri

doi:10.1016/j.addr.2020.06.010

Physical triggering strategies for drug delivery

Adv Drug Deliv Rev. 2020:158:36-62. doi: 10.1016/j.addr.2020.06.010. Epub 2020 Jun 24.

Authors

Tao Sun¹, Anshuman Dasgupta², Zongmin Zhao³, Md Nurunnabi⁴, Samir Mitragotri⁵

Affiliations

¹ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
³ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
⁴ Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, TX 79902, USA.
⁵ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: mitragotri@seas.harvard.edu.

PMID: 32589905
DOI: 10.1016/j.addr.2020.06.010

Abstract

Physically triggered systems hold promise for improving drug delivery by enhancing the controllability of drug accumulation and release, lowering non-specific toxicity, and facilitating clinical translation. Several external physical stimuli including ultrasound, light, electric fields and magnetic fields have been used to control drug delivery and they share some common features such as spatial targeting, spatiotemporal control, and minimal invasiveness. At the same time, they possess several distinctive features in terms of interactions with biological entities and/or the extent of stimulus response. Here, we review the key advances of such systems with a focus on discussing their physical mechanisms, the design rationales, and translational challenges.

Keywords: Controlled release; Drug delivery; Electric field; Light; Magnetic field; Physical triggers; Ultrasound.

Publication types

Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Blood-Brain Barrier / metabolism
Delayed-Action Preparations
Drug Carriers / administration & dosage
Drug Delivery Systems / methods*
Electricity*
Electroporation / methods
Humans
Iontophoresis / methods
Magnetic Fields*
Nanoparticles / administration & dosage
Phototherapy / methods*
Ultrasonography / methods*

Substances

Delayed-Action Preparations
Drug Carriers