Orbitofrontal involvement in a neuroCOVID-19 patient

Loïc Le Guennec; Julia Devianne; Laurence Jalin; Albert Cao; Damien Galanaud; Vincent Navarro; David Boutolleau; Benjamin Rohaut; Nicolas Weiss; Sophie Demeret

doi:10.1111/epi.16612

Orbitofrontal involvement in a neuroCOVID-19 patient

Epilepsia. 2020 Aug;61(8):e90-e94. doi: 10.1111/epi.16612. Epub 2020 Jul 23.

Authors

Loïc Le Guennec^{1

2

3}, Julia Devianne^{1

2}, Laurence Jalin^{2

4}, Albert Cao^{1

2}, Damien Galanaud^{2

5}, Vincent Navarro^{2

3

6}, David Boutolleau^{2

7}, Benjamin Rohaut^{1

2

3

8}, Nicolas Weiss^{1

2

3}, Sophie Demeret^{1

2

3}

Affiliations

¹ Neurology Department, Neurological Intensive Care Unit, Pitié-Salpêtrière Hospital, AP-HP.Sorbonne Université, Paris, France.
² Sorbonne Université, Paris, France.
³ Brain Institute Paris, ICM (Inserm, CNRS, Sorbonne Université), Paris, France.
⁴ Neurosurgical Intensive Care Unit, Pitié-Salpêtrière Hospital, AP-HP.Sorbonne Université, Paris, France.
⁵ Neuroradiology Department, Hôpital Pitié-Salpêtrière, Pitié-Salpêtrière Hospital, AP-HP.Sorbonne Université, Paris, France.
⁶ Neurology and Neurophysiology Department, Hôpital Pitié-Salpêtrière, Pitié-Salpêtrière Hospital, AP-HP.Sorbonne Université, Paris, France.
⁷ Virology Department, Pitié-Salpêtrière Hospital, AP-HP.Sorbonne Université, Paris, France.
⁸ Department of Neurology, Columbia University, New York, New York.

Abstract

Neurological manifestations of coronavirus disease 19 (COVID-19) such as encephalitis and seizures have been reported increasingly, but our understanding of COVID-19-related brain injury is still limited. Herein we describe prefrontal involvement in a patient with COVID-19 who presented prior anosmia, raising the question of a potential trans-olfactory bulb brain invasion.

Publication types

Case Reports

MeSH terms

Aged
Brain Diseases / pathology*
Brain Diseases / physiopathology
Brain Diseases / virology*
COVID-19 / complications*
COVID-19 / pathology
COVID-19 / physiopathology
Frontal Lobe / pathology*
Frontal Lobe / physiopathology
Humans
Male
SARS-CoV-2
Status Epilepticus / pathology
Status Epilepticus / physiopathology
Status Epilepticus / virology*