Case Report: Renal Failure due to Focal Segmental Glomerulosclerosis in a Patient with Murine Typhus

Am J Trop Med Hyg. 2020 Sep;103(3):1017-1019. doi: 10.4269/ajtmh.20-0116.

Abstract

Murine typhus is a flea-borne rickettsiosis caused by Rickettsia typhi. When severe, endothelial dysfunction can lead to acute kidney injury secondary to prerenal azotemia or acute tubular necrosis. Here, we describe an unusual cause of kidney injury during the course of murine typhus-focal segmental glomerulosclerosis.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Animals
  • Apolipoprotein L1 / genetics*
  • Black or African American
  • Genetic Predisposition to Disease
  • Glomerulosclerosis, Focal Segmental / etiology
  • Glomerulosclerosis, Focal Segmental / genetics*
  • Glomerulosclerosis, Focal Segmental / microbiology
  • Glomerulosclerosis, Focal Segmental / pathology
  • Humans
  • Insect Vectors / microbiology
  • Kidney Function Tests
  • Male
  • Mutation
  • Renal Insufficiency / etiology
  • Renal Insufficiency / genetics*
  • Renal Insufficiency / microbiology
  • Renal Insufficiency / pathology
  • Rickettsia typhi / pathogenicity*
  • Siphonaptera / microbiology
  • Typhus, Endemic Flea-Borne / complications
  • Typhus, Endemic Flea-Borne / genetics*
  • Typhus, Endemic Flea-Borne / microbiology
  • Typhus, Endemic Flea-Borne / pathology

Substances

  • APOL1 protein, human
  • Apolipoprotein L1