ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease

J Exp Med. 2020 Jul 6;217(7):e20200885. doi: 10.1084/jem.20200885.

Abstract

ZBP1 triggers NLRP3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous. Recent studies, including Devos et al. in this issue of JEM (https://doi.org/10.1084/jem.20191913), collectively suggest that ZBP1 sensing Z-nucleic acids is critical for cell death/inflammatory disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Biology
  • Humans
  • Inflammation
  • Keratinocytes
  • Necroptosis*
  • Nucleic Acids*
  • RNA-Binding Proteins

Substances

  • Nucleic Acids
  • RNA-Binding Proteins