Abstract
An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the introduction of a negative charge at the C-terminal tail of ribosomal protein S15. Our results help provide a chemical rationale towards understanding how G2019S LRRK2, a common clinical mutation, causes Parkinson's disease.
MeSH terms
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Cryoelectron Microscopy
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Humans
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Mutation*
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Parkinson Disease / metabolism
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Peptides / chemistry
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Peptides / metabolism
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Phosphorylation
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Recombinant Proteins / chemistry
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Ribosomal Proteins / chemistry*
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Ribosomal Proteins / genetics
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Ribosomal Proteins / metabolism*
Substances
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Peptides
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Recombinant Proteins
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Ribosomal Proteins
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ribosomal protein S15