HaDeX: an R package and web-server for analysis of data from hydrogen-deuterium exchange mass spectrometry experiments

Bioinformatics. 2020 Aug 15;36(16):4516-4518. doi: 10.1093/bioinformatics/btaa587.

Abstract

Motivation: Hydrogen-deuterium mass spectrometry (HDX-MS) is a rapidly developing technique for monitoring dynamics and interactions of proteins. The development of new devices has to be followed with new software suites addressing emerging standards in data analysis.

Results: We propose HaDeX, a novel tool for processing, analysis and visualization of HDX-MS experiments. HaDeX supports a reproducible analytical process, including data exploration, quality control and generation of publication-quality figures.

Availability and implementation: HaDeX is available primarily as a web-server (http://mslab-ibb.pl/shiny/HaDeX/), but its all functionalities are also accessible as the R package (https://CRAN.R-project.org/package=HaDeX) and standalone software (https://sourceforge.net/projects/HaDeX/).

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Deuterium
  • Deuterium Exchange Measurement*
  • Hydrogen
  • Hydrogen Deuterium Exchange-Mass Spectrometry*
  • Mass Spectrometry
  • Software

Substances

  • Hydrogen
  • Deuterium