Anaphylaxis to clindamycin following cutaneous exposure

N Paradis; L Marois; L Paradis; F Graham; P Bégin; A Des Roches

doi:10.1186/s13223-020-00452-y

Anaphylaxis to clindamycin following cutaneous exposure

Allergy Asthma Clin Immunol. 2020 Jun 19:16:51. doi: 10.1186/s13223-020-00452-y. eCollection 2020.

Authors

N Paradis¹, L Marois¹, L Paradis^{1

2}, F Graham^{1

2}, P Bégin^{1

2

3}, A Des Roches^{1

3}

Affiliations

¹ Pediatric Allergy and Clinical Immunology, CHU Sainte-Justine, 3175 chemin de la Côte-Sainte-Catherine, Montreal, QC H3T 1C5 Canada.
² Allergy and Clinical Immunology, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Canada.
³ Applied Clinical Research Unit, CHU Sainte-Justine, Montreal, Canada.

Abstract

Background: The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

Case presentation: We describe the first case of intravenous clindamycin anaphylaxis, with likely sensitization due to previous topical exposure to clindamycin gel for acne in a 14-year-old boy with history of atopy and mild atopic dermatitis.

Conclusion: This case highlights the potential sensitization to drug allergens, including antibiotics, via the skin.

Keywords: Antibiotic anaphylaxis; Atopic dermatitis; Transcutaneous exposition.

Publication types

Case Reports