Abstract
2-Mercaptobenzoxazole is a widely used organic scaffold in medicinal chemistry. By means of kinetic and structural studies, we demonstrate that this molecule can effectively be used to inhibit hCAs showing a peculiar binding mode. The results reported here can pave the way for the development of selective CA inhibitors.
MeSH terms
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Amino Acid Sequence
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Benzoxazoles / chemistry*
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Benzoxazoles / metabolism
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Carbonic Anhydrase Inhibitors / chemistry*
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Carbonic Anhydrase Inhibitors / metabolism
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Carbonic Anhydrases / metabolism*
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Catalytic Domain
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Humans
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Kinetics
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Models, Molecular
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Protein Binding
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Protein Conformation
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Structure-Activity Relationship
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Sulfhydryl Compounds / chemistry*
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Sulfhydryl Compounds / metabolism
Substances
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Benzoxazoles
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Carbonic Anhydrase Inhibitors
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Sulfhydryl Compounds
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2-mercaptobenzoxazole
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Carbonic Anhydrases