An "in silico" Bench to Bedside Approach to Investigating Sepsis Biomarkers

Stud Health Technol Inform. 2020 Jun 16:270:1195-1196. doi: 10.3233/SHTI200359.

Abstract

Sepsis results in various patient complications and is due to a heightened inflammatory response against infection. This condition requires further exploration of biomarkers. We employed an "in silico" method comprised of text-mining and additionally clinical validation through the Medical Information Mart for Intensive Care. We highlight that Factor VIII shows potential as a pertinent septic shock biomarker.

Keywords: Bioinformatics; Biomarkers; Natural language processing; Sepsis.

MeSH terms

  • Biomarkers
  • Humans
  • Sepsis*

Substances

  • Biomarkers