Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis

Abigail Kindberg; Jimmy K Hu; Jeffrey O Bush

doi:10.1016/j.ceb.2020.05.004

Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis

Curr Opin Cell Biol. 2020 Oct:66:59-68. doi: 10.1016/j.ceb.2020.05.004. Epub 2020 Jun 20.

Authors

Abigail Kindberg¹, Jimmy K Hu², Jeffrey O Bush³

Affiliations

¹ Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
² School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: jkhu@g.ucla.edu.
³ Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA. Electronic address: Jeffrey.bush@ucsf.edu.

Abstract

Morphogenesis is a physical process that requires the generation of mechanical forces to achieve dynamic changes in cell position, tissue shape, and size as well as biochemical signals to coordinate these events. Mechanical forces are also used by the embryo to transmit detailed information across space and detected by target cells, leading to downstream changes in cellular properties and behaviors. Indeed, forces provide signaling information of complementary quality that can both synergize and diversify the functional outputs of biochemical signaling. Here, we discuss recent findings that reveal how mechanical signaling and biochemical signaling are integrated during morphogenesis and the possible context-specific advantages conferred by the interactions between these signaling mechanisms.

Keywords: Actomyosin; Development; Eph; Ephrin; Force; Morphogenesis; PIEZO; Signaling; Taz; Tension; Yap.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Biomechanical Phenomena
Cell Count
Humans
Mechanotransduction, Cellular*
Models, Biological
Morphogenesis*
Signal Transduction*

Abstract

Publication types

MeSH terms

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