National Dementia BioBank: A Strategy for the Diagnosis and Study of Neurodegenerative Diseases in México

J Alzheimers Dis. 2020;76(3):853-862. doi: 10.3233/JAD-191015.

Abstract

We recently developed the National Dementia Biobank in México (BioBanco Nacional de Demencias, BND) as a unit for diagnosis, research, and tissue transfer for research purposes. BND is associated with the Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico (UNAM), Mexico. The donation of fluids, brain, and other organs of deceased donors is crucial for understanding the underlying mechanisms of neurodegenerative diseases and for the development of successful treatment. Our laboratory research focuses on 1) analysis of the molecular processing of the proteins involved in those neurodegenerative diseases termed tauopathies and 2) the search for biomarkers for the non-invasive and early diagnosis of Alzheimer's disease.

Keywords: Alzheimer’s disease; BioBank; amyloid-β; brain tissue; neurodegenerative disease; tau protein; tauopathies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / pathology*
  • Biological Specimen Banks* / standards
  • Biomarkers / metabolism
  • Brain / metabolism
  • Brain / pathology*
  • Humans
  • Mexico
  • Neurodegenerative Diseases / pathology*
  • Tauopathies / pathology*
  • tau Proteins / metabolism

Substances

  • Biomarkers
  • tau Proteins