Poly (acrylic acid) (PAA) is a contact system activator with properties to stop hemorrhage

Gabriel L Forbes; Alona Merkulova; Alexandro Pinheiro; Jasmine Lee; Peng Zeng; Sarah Abdalian; Anne Y Walker; Gary E Wnek; Alvin H Schmaier

doi:10.1016/j.thromres.2020.06.011

Poly (acrylic acid) (PAA) is a contact system activator with properties to stop hemorrhage

Thromb Res. 2020 Sep:193:142-145. doi: 10.1016/j.thromres.2020.06.011. Epub 2020 Jun 6.

Authors

Gabriel L Forbes¹, Alona Merkulova¹, Alexandro Pinheiro¹, Jasmine Lee¹, Peng Zeng¹, Sarah Abdalian¹, Anne Y Walker², Gary E Wnek², Alvin H Schmaier³

Affiliations

¹ Division of Hematology and Oncology and Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States of America.
² Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, United States of America.
³ Division of Hematology and Oncology and Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, United States of America; University Hospitals Cleveland Medical Center, Cleveland, OH 44106, United States of America. Electronic address: alvin.schmaier@case.edu.

PMID: 32559571
DOI: 10.1016/j.thromres.2020.06.011

No abstract available

Keywords: Contact activation; Factor XII autoactivation; Hemostatic agent; Murine bleeding assay; Poly(acrylic acid); Thrombin generation; Wound bleeding.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Acrylates
Hemorrhage*
Humans

Substances

Acrylates
acrylic acid

Grants and funding

R21 CA223301/CA/NCI NIH HHS/United States