Peptide-Based PROTAC: The Predator of Pathological Proteins

Yan Zi Au; Tingjian Wang; Logan H Sigua; Jun Qi

doi:10.1016/j.chembiol.2020.06.002

Peptide-Based PROTAC: The Predator of Pathological Proteins

Cell Chem Biol. 2020 Jun 18;27(6):637-639. doi: 10.1016/j.chembiol.2020.06.002.

Authors

Yan Zi Au¹, Tingjian Wang¹, Logan H Sigua¹, Jun Qi²

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: jun_qi@dfci.harvard.edu.

PMID: 32559499
DOI: 10.1016/j.chembiol.2020.06.002

Abstract

Qu et al. (2020) demonstrate a peptide-induced targeted degradation of the alpha-synuclein protein, a hallmark of Parkinson's disease. Using a modular three-component design, the target-protein-specific, cell-permeable peptide disposed of alpha-synuclein via the ubiquitin-proteasome pathway rather than the standard autophagy-lysosome pathway.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Autophagy
Proteasome Endopeptidase Complex*
alpha-Synuclein*

Substances

alpha-Synuclein
Proteasome Endopeptidase Complex

Abstract

Publication types

MeSH terms

Substances

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