Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells

Rachel Thijssen; Silvia Alvarez-Diaz; Clea Grace; Ming-Yuan Gao; David H Segal; Zhen Xu; Andreas Strasser; David C S Huang

doi:10.1038/s41418-020-0576-2

Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells

Cell Death Differ. 2020 Aug;27(8):2531-2533. doi: 10.1038/s41418-020-0576-2. Epub 2020 Jun 18.

Authors

Rachel Thijssen^#^{1

2}, Silvia Alvarez-Diaz^#^{1

2}, Clea Grace^{1

3}, Ming-Yuan Gao^{1

2}, David H Segal^{1

2}, Zhen Xu^{1

2}, Andreas Strasser^{4

5}, David C S Huang^{6

7}

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
² Department of Medical Biology, University of Melbourne, Parkville, VIC, 3050, Australia.
³ St Vincent's Institute of Medical Research, Fitzroy, VIC, 3065, Australia.
⁴ The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. strasser@wehi.edu.au.
⁵ Department of Medical Biology, University of Melbourne, Parkville, VIC, 3050, Australia. strasser@wehi.edu.au.
⁶ The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. huang_d@wehi.edu.au.
⁷ Department of Medical Biology, University of Melbourne, Parkville, VIC, 3050, Australia. huang_d@wehi.edu.au.

^# Contributed equally.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use*
Carcinogenesis / metabolism
Carcinogenesis / pathology*
Cell Death / drug effects
Kaplan-Meier Estimate
Lymphoma / drug therapy*
Lymphoma / metabolism
Lymphoma / pathology*
Mice, Transgenic
Proto-Oncogene Proteins c-myc / metabolism*
Receptor-Interacting Protein Serine-Threonine Kinases / deficiency*
Receptor-Interacting Protein Serine-Threonine Kinases / metabolism

Substances

Antineoplastic Agents
Proto-Oncogene Proteins c-myc
Receptor-Interacting Protein Serine-Threonine Kinases
Ripk3 protein, mouse