Abstract
The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis.
Keywords:
Anti-viral response; Nonsense-mediated mRNA decay; RNA biology; Viruses.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Codon, Nonsense
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Host-Pathogen Interactions / genetics
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Humans
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Nonsense Mediated mRNA Decay*
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Protein Binding
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Protein Biosynthesis
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RNA Helicases / genetics
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RNA Helicases / metabolism
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RNA, Messenger / genetics*
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RNA, Messenger / metabolism
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RNA, Viral / genetics*
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RNA, Viral / metabolism
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / metabolism
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Ribosomes / genetics
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Ribosomes / metabolism
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Signal Transduction
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Viral Proteins / genetics*
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Viral Proteins / metabolism
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Virus Diseases / genetics*
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Virus Diseases / metabolism
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Virus Diseases / pathology
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Virus Diseases / virology
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Viruses / classification
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Viruses / genetics*
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Viruses / growth & development
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Viruses / pathogenicity
Substances
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Codon, Nonsense
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RNA, Messenger
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RNA, Viral
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RNA-Binding Proteins
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Trans-Activators
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Viral Proteins
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RNA Helicases
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UPF1 protein, human