Caspase-8 and FADD: Where Cell Death and Inflammation Collide

Marcelo Pires Amaral; Karina Ramalho Bortoluci

doi:10.1016/j.immuni.2020.05.008

Caspase-8 and FADD: Where Cell Death and Inflammation Collide

Immunity. 2020 Jun 16;52(6):890-892. doi: 10.1016/j.immuni.2020.05.008.

Authors

Marcelo Pires Amaral¹, Karina Ramalho Bortoluci²

Affiliations

¹ Center for Cellular and Molecular Therapy (CTCMol), Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
² Center for Cellular and Molecular Therapy (CTCMol), Federal University of São Paulo (UNIFESP), São Paulo, Brazil. Electronic address: kbortoluci@gmail.com.

PMID: 32553174
DOI: 10.1016/j.immuni.2020.05.008

Abstract

Caspase-8 is a master regulator of cell death pathways, although its regulation during inflammation remains elusive. Using elegant mouse genetic approaches, Schwarzer et al. and Tummers et al. revealed the importance of FADD in regulating caspase-8-mediated inflammatory responses and gut homeostasis.

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MeSH terms

Animals
Apoptosis
Caspase 8 / genetics
Caspase 8 / metabolism
Cell Death
Epithelial Cells / metabolism
Fas-Associated Death Domain Protein / genetics
Fas-Associated Death Domain Protein / metabolism
Gastrointestinal Microbiome*
Homeostasis
Inflammation
Intracellular Signaling Peptides and Proteins
Mice
Phosphate-Binding Proteins
Protein Kinases

Substances

Fadd protein, mouse
Fas-Associated Death Domain Protein
Gsdmd protein, mouse
Intracellular Signaling Peptides and Proteins
Phosphate-Binding Proteins
MLKL protein, mouse
Protein Kinases
Caspase 8