Objective: To investigate the prognostic evaluation value of neutrophil-lymphocyte ratio (NLR) in patients with newly diagnosed angioimmunoblastic T cell lymphoma (AITL).
Methods: Clinical data of 39 patients with newly diagnosed AITL in our hospital from March 2010 to August 2018 were colleated and retrospective analyzied, and the relationship between NLR before treatment and the prognosis of AITL patients was analyzed.
Results: Among 39 AITL patients, the median value of NCR was 5.43. Based on the cut-off value (5.43), all the patients were divided into 2 groups: high NLR group (5.43, n=20) and a low NLR group (＜5.43, n=19). The total effective rate of treatment was lower in the high NLR group as compered with low NLR group (P=0.041). Univariate analysis showed that, age ＞60 years old, extranodal involvement＞1 as well as high NLR were the independent risk factors that affected overall survival (OS) in newly diagnosed AITL patients. Multivariate Cox analysis showed that extranodal involvement＞1 and high NLR were the independent risk factors that affected OS in newly diagnosed AITL patients.
Conclusion: The NLR may be an independent prognostic factor in patients with newly diagnosed AITL. High NLR associated with poor prognosis.
题目: 中性粒细胞/淋巴细胞比值在初诊血管免疫母细胞性T细胞淋巴瘤患者预后分析中的价值.
目的: 探讨外周血中性粒细胞/淋巴细胞比值（NLR）在初诊血管免疫母细胞性T细胞淋巴瘤（AITL）患者预后评估中的价值.
方法: 回顾性分析2010年3月至2018年8月在皖南医学院第一附属医院收治的AITL初诊患者临床资料39例，分析治疗前NLR与AITL患者预后的关系.
结果: 39例AITL患者初诊NLR中位数为5.43，以此中位值为临界值，将AITL患者分成高NLR组（NLR≥5.43，20例）和低NLR组（NLR＜5.43，19例）。与低NLR患者相比，高NLR组患者治疗总有效率更低（P=0.041）。单因素分析结果显示，年龄＞60岁、结外受累部位2个及以上及高NLR是影响患者总生存的不良预后因素。Cox多因素分析结果显示，结外受累部位2个及以上和高NLR是影响患者预后的独立危险因素.
结论: 外周血NLR水平是影响初诊AITL患者的预后因素，NLR升高提示患者预后不良.