Comparisons of quality of life between patients underwent peritoneal dialysis and hemodialysis: a systematic review and meta-analysis

Anan Chuasuwan; Siriporn Pooripussarakul; Ammarin Thakkinstian; Atiporn Ingsathit; Oraluck Pattanaprateep

doi:10.1186/s12955-020-01449-2

Comparisons of quality of life between patients underwent peritoneal dialysis and hemodialysis: a systematic review and meta-analysis

Health Qual Life Outcomes. 2020 Jun 18;18(1):191. doi: 10.1186/s12955-020-01449-2.

Authors

Anan Chuasuwan^{1

2}, Siriporn Pooripussarakul¹, Ammarin Thakkinstian¹, Atiporn Ingsathit^{1

3}, Oraluck Pattanaprateep⁴

Affiliations

¹ Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd., Ratchathewi, Bangkok, Thailand.
² Nephrology Division, Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
³ Nephrology Division, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
⁴ Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd., Ratchathewi, Bangkok, Thailand. Oraluck.pat@mahidol.ac.th.

Abstract

Objective: End-stage renal disease (ESRD) leads to renal replacement therapy and certainly has an impact on patients' health-related quality of life (HRQoL). This study aimed to review and compare the HRQoL between peritoneal dialysis (PD) and hemodialysis (HD) patients using the 36-Item Short Form Health Survey (SF-36), EuroQoL-5-dimension (EQ-5D) and the Kidney Disease Quality of Life Instrument (KDQOL).

Methodology: Systematic review was conducted by identify relevant studies through MEDLINE and SCOPUS up to April 2017. Studies were eligible with following criteria: studied in ESRD patients, compare any pair of renal replacement modalities, and reported HRQoL. The unstandardized mean differences (USMD) of HRQoL among modalities were calculated and pooled using a random-effect models if heterogeneity was present, otherwise a fixed-effect model was applied.

Results: A total of twenty-one studies were included with 29,000 participants. Of them, mean age and percent male were 48.1 years and 45.1, respectively. The pooled USMD (95% CI) of SF-36 between PD and HD (base) were 1.86 (0.47, 3.24) and 0.42 (- 1.99, 2.82) for mental component and physical component summary scores, respectively. For EQ-5D, the pooled USMD of utility and visual analogue scale (VAS) score were 0.02 (- 0.06, 0.10) and 3.56 (1.73, 5.39), respectively. The pooled USMD of KDQOL were 9.67 (5.67, 13.68), 6.71 (- 5.92, 19.32) 6.30 (- 0.41, 12.18), 2.35 (- 4.35, 9.04), 2.10 (0.07, 4.13), and 1.21 (- 2.98, 5.40) for burden of kidney disease, work status, effects of kidney disease, quality of social interaction, symptoms, and cognitive function.

Conclusion: Patients with chronic kidney disease (CKD) stage 5 or ESRD treated with PD had better generic HRQoL measured by SF-36 and EQ-5D than HD patients. In addition, PD had higher specific HRQoL by KDQOL than HD patients in subdomain of physical functioning, role limitations due to emotional problems, effects and burden of kidney disease.

Keywords: EQ-5D; Health-related quality of life; Hemodialysis; KDQOL; Peritoneal dialysis.

Publication types

Comparative Study
Meta-Analysis
Systematic Review

MeSH terms

Adult
Aged
Disease Progression
Female
Humans
Kidney Failure, Chronic / psychology
Kidney Failure, Chronic / therapy
Male
Middle Aged
Peritoneal Dialysis / adverse effects
Peritoneal Dialysis / psychology*
Quality of Life*
Renal Dialysis / adverse effects
Renal Dialysis / psychology*
Surveys and Questionnaires